Spectral Indices of Cardiac Autonomic Function in Obstructive Sleep Apnea

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Spectral indices of cardiac autonomic function in obstructive sleep apnea.

Spectral analysis of heart rate variability (HRV) is useful as a noninvasive means of assessing autonomic function in patients with obstructive sleep apnea (OSA). However, standard spectral measures, such as the ratio of low-frequency to high-frequency power (LHR) and normalized high-frequency power (NHFP), can be confounded by the abnormal breathing patterns that occur during sleep. To circumv...

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INTRODUCTION The sympathetic activation is considered to be the main mechanism involved in the development of cardiovascular diseases in obstructive sleep apnea (OSA). The heart rate variability (HRV) analysis represents a non-invasive tool allowing the study of the autonomic nervous system. The impairment of HRV parameters in OSA has been documented. However, only a few studies tackled the dyn...

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Autonomic Function in Adults with Obstructive Sleep Apnea

Background: Obstructive Sleep Apnea (OSA) is the most prevalent form of sleep disordered breathing and could become an important public health issue in India. Patients with OSA have high levels of sympathetic nerve activity during sleep. The autonomic alterations persist during wakefulness and are considered to contribute to the cardiovascular disorders associated with OSA. Aims & Objective: Th...

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Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea

OBJECTIVE To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS Thirteen male patients with severe obstructive sleep apnea (mean age 43+/-10 years with a mean body mass index of 26.7+/-1.9 kg/m(2)) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability wer...

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ژورنال

عنوان ژورنال: Sleep

سال: 1999

ISSN: 1550-9109,0161-8105

DOI: 10.1093/sleep/22.4.443